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细胞电生理设备
A-M Systems电生理系列产
在Science, Nature, Neuroscience等权威期刊上引用。产品覆盖膜片钳放大器、细胞内/外放大器、刺激信号发生器、信号采集等电生理实验必备仪器及其配件。   膜片钳放大器   Model 2400 膜片钳放大器   产品特点:   l 全功能膜片钳,实现全细胞记录及和膜片记录   l 可切换的双阻反馈探头   l 提供电容、电阻、及全细胞补偿机制   l 四极贝塞尔低通滤波器   l 可自发测试信号   l 内置液晶屏显示关键数据   l 前面板操作记录可报表输出   l 三年质保   引用案例:   l Smith AJ, Sugita S, and Charlton MP. (2010) Cholesterol-dependent kinase activity regulates transmitter release from cerebellar synapses. J Neuroscience 30(17): 6116-6121   l Del Negro CA et al. (2009) Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiology 587: 1217-1231   l Olsen SR and Wilson RI. (2008) Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452:956-960   l Yao CA, Ingell R, and Carlson JR (2005) Chemosensory coding by neurons in the coeloconic sensilla of the Drosophila Antenna. J Neuroscience 25(37): 8359-8367   _____________________________________________________________________________________________________________________________   细胞内放大器   Model 3100 细胞内放大器   产品特点:   l 方波发生器可测试电极电阻和电容补偿   l 单个电极可同时刺激和记录   l 低通和陷波滤波器   l 电极阻抗可测量   主要参数:   l Noise (10Hz - 50kHz): 18 μV, rms shorted; < 350 μV with 20 Megohm source   l Input impedance: 10^13 ohms; capacitance adjustable to zero   l Bias current: Adjustable to zero   l Voltage gain: x1 and x10   l Capacity Compensation: -4 pF - 35 pF   l DC Offset: ±1 V   l Max internal current: 1 μA   l External current: 100 nA/V; 10 V maximum   l Electrode test: 100 Hz, 10 nA; (i.e. 10 mV/Megohm electrode resistance)   l Ringer: 0 - 10 V biphasic, 2 - 8 kHz   引用案例:   l Suadicani SO et al. (2009) Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes. ASN Neuro 1(1):55-63   l Lowe GC, Luheshi GN, and Williams S (2008) Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats. Am J Physiol Regul Integr Comp Physiol 295: R1563-R1571   ____________________________________________________________________________________________________________________________   细胞外放大器   Model 1700四通道差分AC放大器   Model 1800双通道微电极AC放大器   Model 1700/1800应用于可兴奋组织(神经和肌肉等)细胞外神经电生理记录,可记录EMG/EEG/EKG/ERG,供教学和科研使用。Model 1800需连接转换头使用。   每通道放大器包含高增益低噪声的差分电极并跟随有低通、高通、陷波滤波器。每路还包含刺激电极,可在同一电极上发生刺激和记录。   主要参数:   l Gain* x100, x1000, x10000   l High Pass Filter* 0.1, 1.0, 10, 100, and 300 Hz; -40 dB / decade   l Low Pass Filter* 500, 1000, 5000, 10000, and 20000 Hz; -40 dB / decade   l Notch Filter >-35dB at 50 or 60 Hz.(Model 1700)   l Notch Filter >-25dB at 50 or -30dB at 60 Hz.(Model 1800)   l Noise 1.0 microvolt p-p typical (10 Hz to 10,000 Hz)   l Common Mode Rejection > 80 dB   标*的参数可根据需要收费定制   引用案例:   l Chen FP and Evinger C (2006) Cerebellar modulation of trigeminal reflex blinks: Interpositus neurons. J Neuroscience 26(41):10569-10576   l Weiss SA, Preuss T, and Faber DS (2009) Phase encoding in the Mauthner system: Implications in left-right sound source discrimination. J euroscience 29(11)3431-3441   l Werk CM and Chapman CA (2003) Long-term potentiation of polysynaptic responses in layer V of the Sensorimotor Cortex induced by Theta-patterned tetanization in the awake rat. Cerebral Cortex 13(5): 500-507   ___________________________________________________________________________________________________________________________   细胞外放大器   Model 3500 16通道差分AC放大器   Model 3600 16通道微电极AC放大器   Model 3500/3600应用于可兴奋组织(神经和肌肉等)细胞外神经电生理记录,可记录EMG/EEG/EKG/ERG,供教学和科研使用。Model 3600需连接转换头使用。   该产品在传统产品的基础上,不仅提供更强大的参数配置功能,并且实验参数还可通过触屏或windows软件控制。日志功能可提供实验数据的时间戳方便数据的整理。   主要参数:   l Gain*: 10, 20, 50, 100, 200, 500, 1000, 2000, 5000,10000, 20000   l High Pass Filter* 0.3, 1.0, 3.0, 10, 30, 100, 300, and 500 Hz; -40 dB / decade   l Low Pass Filter* 0.1, 0.3, 0.5, 1.0, 3.0, 5.0, 10.0, and 20.0 kHz; -40 dB / decade   l Notch Filter >-35 dB at 50 or 60 Hz.   l Noise: 2.0 microvolt rms typical (10 Hz to 10,000 Hz)   标*的参数可根据需要收费定制   引用案例:   l Lu H, et al. (2007) Synchronized delta oscillations correlate with the resting-state functional MRI signal. PNAS 104 (46): 18265-18269   l Viggiano A., et al. (2010) Mastication overload causes an increase in O2- production into the subnucleus oralis of the spinal trigeminal nucleus Neuroscience 166(2):416-421   ____________________________________________________________________________________________________________________________   刺激发生器   Model 3800 八路可编程刺激发生器   Model 3800 八路可编程刺激发生器应用非常广泛。它高度灵活,可同时发生8路单相或两相脉冲序列,此外,使用内置协议,可非常容易地发生步进脉冲或成对脉冲。   主要参数:   l Timing Rage: 1 μs to 250 Hours   l Minimum Pulse Duration: 1 μs monophasic; 2μs biphasic   l Minimum Pulse Interval: 1 μs monophasic; 2μs biphasic   l Timing Accuracy: Better than 0.02%   l Output: ± 10 V; ± 20 mA, with 1mV resolution   l With Optional SIU: ± 100 V; ±10 mA, with selectable AC coupling; 500kHz bandwidth   l Built-in Stimulus Protocols: Monophasic, Biphasic, Paired Pulse, and Stepped pulse   l Triggering: 8 Channel-specific rear panel BNCs; 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel triggering   l Gating: 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel gating   ____________________________________________________________________________________________________________________________   刺激发生器   Model 4100 单通道高能可编程刺激发生器   Model 4100 是A-M Systems公司推出的功能最强大、使用最灵活的可编程刺激发生器,在各种场景得到广泛应用。发生器可发生多种波形,并且用户和通过自定义发生需要的波形。   典型应用:   l long-term potentiation (LTP)   l nerve conduction   l long-term depression (LTD)   l evoked potentials   l classical conditioning   l lesions   l field stimulation   l kindling / seizure models   主要参数:   l Amplitude: -200 V to 200 V @ 100 mA   l Minimum Event Width: 1 microsecond   l Maximum Event Width: 25 hours   l Minimum Event Interval: 2 microseconds   l Bandwidth: 1MHz   l Trigger Options: Manual, External, or Free-Run   l Software: Windows, OSx, Matlab, LabView, iOS, Android